Abstract: Optical coherence tomography (OCT) is a noncontact, good repeatability technique to obtain fastly highresolution images from the anterior and posterior segments of the eye, and it has been widely used in the field of ophthalmology. Previous studies have shown that the thickness of circumpapillary retinal nerve fibre layer (cpRNFL) and optic disc assessment with OCT are valuable in diagnosing glaucoma.Traditional time domain (TD) OCT can measure macular nerve epithelium thickness.However, spectraldomain(SD) OCT allows a higher image resolution and can measure the thickness of retinal ganglion cell complex, which has less variablity in normal subjects so to be used as better indicator for early diagnosis in glaucoma. In this paper, we review the macular thickness measurement with OCT in glaucoma early diagnosis.   (Int Rev Ophthalmol, 2014, 38:   305-308)